Basilica of Saint Mary Major

Built in the 9th century, this ancient basilica crowns the top of the Esquiline Hill. Tons of gold decorate the interior together with impressive mosaics (particularly when the floodlights are turned on), and there is a museum on the premises. If you are in Rome on Corpus Christi (Corpus Domini), which is the Thursday after the 8th Sunday after Easter, an early-evening service is held in San Giovanni by the Pope followed by a procession along Via Merulana to Santa Maria. Good opportunity for a close up view of the Pope. This is a very large church with lots to see, as for example, the main part of the church has two layers of mosaics and paintings high on the walls, the altar and apse are spectacular, and then there are several more or less large chapels you won't want to miss, including the one with the amazing golden baptismal font. Allow at least an hour if not an hour and a half or more to visit the interior, even if you do not take any special tours, and also allow time to view the exterior from all sides. Overall, at least 2 hours would not be too much time to allot.

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